Signal Transduct Target Ther

期刊全称Signal Transduct Target Ther
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期刊相关文献 (195)

Nature-inspired confined cascade enzyme nanoreactors for targeted atherosclerosis therapy

受自然启发的受限级联酶纳米反应器用于靶向动脉粥样硬化治疗

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:10.1038/s41392-026-02598-4.
Yuehuang Wu #,Hongping Xia #,He Ding,Mengmeng Long,Sen Yan,Miao Zhang,Jingyi Sheng,Ning Gu
动脉粥样硬化
发表日期：2026
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Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer

泛素介导的KDM5B稳定化通过抑制双特异性磷酸酶4驱动卵巢癌的化疗耐药性

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:10.1038/s41392-026-02601-y
Jung Yoo,Go Woon Kim,Yu Hyun Jeon,Jaewook Kim,Enzhi Luo,Sang Wu Lee,Soo Yeon Oh,Junjeong Choi,Kuglae Kim,So Hee Kwon
卵巢癌
肿瘤
表观遗传
KDM5B
m6A/m5C/m7G
发表日期：2026
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Inducible CD147 up-regulation boosts extended SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2

诱导型 CD147 上调可延长 SARS-CoV-2 感染，并引发重症 COVID-19，且该过程独立于 ACE2。

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:10.1038/s41392-025-02551-x
Ke Wang #,Peng Lin #,Ruo Chen #,Qiang Huang #,Yizhen Zhao #,Lei Zhang,Yongxiang Zhao,Liping Zhong,Ke Xu,Linlin Bao,Youchun Wang,Chuan Qin,Guizhen Wu,Hai Zhang,Jiejie Geng,Zheng Zhang,Ding Wei,Xiaochun Chen,Hao Tang,Liu Yang,Xu Yang,Xiuxuan Sun,Rui Yao,Ye Zhao,Weijun Qin,Zhiwei Yang,Liang Chen,Huijie Bian,Zhi-Nan Chen,Ping Zhu
新冠
炎症/感染
ACE2
CD14
SARS-CoV-2
CD147
发表日期：2026
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Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses

选择性地清除肿瘤相关SAMHD1可增强化疗疗效和抗肿瘤免疫反应。

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:10.1038/s41392-025-02523-1.
Jing Sun #,Wenwen Zheng #,Zheng-Guo Zhang #,Hongkun Zhou #,Songdi Wang #,Dingbo Huang,Xiao-Yi Hu,Qing-Feng Yu,Zhao-Xing Wu,Yi-Fei Shi,Runxin Ye,Fengyan Xia,Wangwei Li,Shurui Lyu,Yu Huang,Xu-Zhao Zhang,Fei Xu,Ke Zhao,Jie Yang,Juan Du,Jiaming Su,Yajuan Rui,Rongzhen Xu,Wei-Ming Yang,Cang Li,Jia Ling Xu,Ruiyu Zhu,Xiaoguang Wang,Wei Wei,Xiao-Fang Yu
肿瘤
免疫/内分泌
SAMHD1
肿瘤免疫
发表日期：2025
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Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop

Piezo1激活通过抑制机械炎症自分泌环路来抑制骨髓脂肪生成，从而预防骨质疏松症。

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:10.1038/s41392-025-02455-w.
Baile Wang #,Jie Liu #,Qin Wang,Malika Arhatte,Lai Yee Cheong,Edyta Glogowska,Xue Jiang,Sookja Kim Chung,Leigang Jin,Qianxing Hu,Yu Wang,Eric Honoré,Aimin Xu
骨质疏松
炎症/感染
ZO1
炎症
发表日期：2025
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GPR15 differentially regulates the effects of cigarette smoke exposure on Crohn's disease and ulcerative colitis

GPR15对香烟烟雾暴露对克罗恩病和溃疡性结肠炎的影响具有不同的调节作用。

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:10.1038/s41392-025-02384-8.
Luhua Gao #,Huaping Zheng #,Qing Zhao #,Yubin Wang #,Yong He #,Can Hou #,Na Yang,Kun Liang,Wenjian Meng,Xuefei He,Kun Zheng,Wenning Tian,Jiacheng Zhang,Ting Zhang,Hui Mao,Liming Zhang,Jingyu Zhang,Jingqiu Cheng,Jürgen Brosius,Huan Song,Yuchuan Huang,Yi Chen,Cheng Deng
肠炎
炎症/感染
发表日期：2025
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Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment

单细胞转录组分析揭示肠道菌群通过调节肿瘤微环境发挥免疫疗法协同作用

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:PMC12045981
Minyuan Cao #，Yun Deng #，Qing Hao #，Huayun Yan #，Quan-Lin Wang #，Chunyan Dong，Jing Wu，Yajiao He，Li-Bin Huang，Xuyang Xia ，Yongchao Gao，Hai-Ning Chen，Wei-Han Zhang，Yan-Jing Zhang，Xiaozhen Zhuo，Lunzhi Dai，Hongbo Hu，Yong Peng，Feng Zhang，Zhaoqian Liu，Weihua Huang，Huiyuan Zhang，Li Yang，Yang Shu，Wei Zhang，Yan Zhang，Heng Xu
细胞生物学
肿瘤
免疫/内分泌
肠道菌群
单细胞
发表日期：2025
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VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment

VCP下游代谢产物甘油-3-磷酸（G3P）抑制HCC微环境中CD8+T细胞的功能

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:PMC11758394
Cheng Cheng # ，Qingrui Zha # ，Linmao Sun # ，Tianming Cui # ，Xinyu Guo，Changjian Xing ，Zhengxiang Chen ，Changyong Ji ，Shuhang Liang ，Shengwei Tao ，Junhui Chu ，Chenghui Wu ，Qi Chu ，Xuetian Gu ，Ning Zhang，Yumin Fu ，Shumin Deng ，Yitong Zhu ，Jiabei Wang ，Yao Liu ，Lianxin Liu
细胞生物学
代谢
T细胞
G3P
VCP
CD8
T细胞
发表日期：2025
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Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10-Notch signaling

α溶血素通过ADAM10-Notch信号通路调节树突状细胞分化，从而增强免疫反应。

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:PMC12508477
Ke Wang ，Jingwen Liao，Yue Yuan，Zhifu Chen，Qiang Gou，Haiming Jing，Mengmeng Liang，Yuanda Tang，Pengju Yan，Xiaoqian Yu，Zhuo Zhao，Tianjun Sun，Zhenping Xia，Ting Yu，Yaling Liao，Hao Zeng，Xiaoli Zhang，Quanming Zou，Jinyong Zhang  0
信号转导
细胞生物学
信号转导
免疫/内分泌
树突状细胞
ADAM10
NOTCH
ADA
OTC
Notch
发表日期：2025
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DNA/RNA-binding protein KIN17 supports esophageal cancer progression via resolving noncanonical STING activation induced by R-loop

DNA/RNA结合蛋白KIN17通过解除R环诱导的非经典STING激活来促进食管癌的进展。

期刊:Signal Transduct Target Ther
影响因子:40.800
doi:PMC12354822
Zichao Wei #，Ning Zhao #，Lu Kuang，Ji Cong，Sujuan Zheng，Yi Li，Zhihua Liu
食管癌
肿瘤
KIN17
STING
发表日期：2025
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