Nature Aging

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.

Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness.

Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis.

DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation.

巨噬细胞中的DNA损伤通过核抗原呈递驱动免疫自身反应。

Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance.

对衰老细胞清除药物的比较分析揭示了线粒体对药物疗效和耐药性的决定因素。

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling.

衰老毒素通过脂质结合特异性、离子失衡和脂质组重塑来靶向衰老。

Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease.

细胞类型特异性 GPR120 的变构激活可抑制阿尔茨海默病的淀粉样蛋白病理。

Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases.

甲羟戊酸代谢物通过小GTP酶的异戊二烯化作用提高衰老卵母细胞的质量。

Regeneration leads to global tissue rejuvenation in aging sexual planarians.

再生作用可使衰老的涡虫组织实现整体再生。