Science Translational Medicine

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread

针对克里米亚-刚果出血热病毒GP38的抗体可限制血管渗漏和病毒传播。

Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia

CD4+ T 细胞中针对自身抗原产生反应的前病毒会导致无法抑制的 HIV-1 病毒血症。

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models

用mRNA编码的膜结合HIV包膜三聚体进行疫苗接种可在动物模型中诱导中和抗体

The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell-mediated transplant rejection

抑制性受体Siglec-E控制抗原呈递细胞活化和T细胞介导的移植排斥反应。

Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma

选择性抑制S6K2可揭示脂质稳态是MAPK抑制剂耐药的NRAS突变型黑色素瘤的生存弱点。

Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis

Orthopedia 调节黑皮质素 4 受体转录和能量稳态

Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.

Lipidomic profiling of mouse brain and human neuron cultures reveals a role for Mboat7 in mTOR-dependent neuronal migration.

Preexisting immunity to the 2009 pandemic H1N1 virus reduces susceptibility to H5N1 infection and disease in ferrets.

G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells.

G6PC2 通过确定胰腺α细胞中葡萄糖的设定点来控制胰高血糖素的分泌。