Scalable units for building cardiac tissue

用于构建心脏组织的可扩展单元

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作者:Xiaofeng Ye, Liang Lu, Martin E Kolewe, Keith Hearon, Kristin M Fischer, Jonathan Coppeta, Lisa E Freed

Abstract

Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart-cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in vivo, may aid in the regenerative repair of vascularized tissues.

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