The activity of albaconazole (UR-9825; J. Uriach & CÃa. S.A., Barcelona, Spain) was compared to that of fluconazole against 12 isolates of Cryptococcus neoformans in vitro and against 1 isolate in vivo in a rabbit model of cryptococcal meningitis. Albaconazole was 100-fold more potent in vitro than fluconazole on a per-weight basis and was fungicidal at potentially relevant concentrations for two isolates. MICs ranged from
In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.
新型三唑类药物阿巴康唑对新型隐球菌的体外和体内疗效。
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| 期刊： | Antimicrobial Agents and Chemotherapy | 影响因子： | 4.500 |
| 时间： | 2004 | 起止号： | 2004 Feb;48(2):384-7 |
| doi： | 10.1128/AAC.48.2.384-387.2004 | ||
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