Intracranial administration of P gene siRNA protects mice from lethal Chandipura virus encephalitis
颅内注射 P 基因 siRNA 可保护小鼠免受致命的 Chandipura 病毒性脑炎的侵害
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作者:Satyendra Kumar, Vidya A Arankalle
| 期刊: | PLoS One | 影响因子: | 2.900 |
| 时间: | 2010 | 起止号: | 2010 Jan 7;5(1):e8615. |
| doi: | 10.1371/journal.pone.0008615 | 研究方向: | 免疫、微生物学、神经 |
| 疾病类型: | 脑炎 | |
Background
In parts of India, Chandipura Virus (CHPV) has emerged as an encephalitis causing pathogen in both epidemic and sporadic forms. This pediatric disease follows rapid course leading to 55-75% mortality. In the absence of specific treatment, effectiveness of RNA interference (RNAi) was evaluated.
Conclusions
The results highlight therapeutic potential of siRNA in treating rapid and fatal Chandipura encephalitis.
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