Intracranial administration of P gene siRNA protects mice from lethal Chandipura virus encephalitis

颅内注射 P 基因 siRNA 可保护小鼠免受致命的 Chandipura 病毒性脑炎的侵害

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作者:Satyendra Kumar, Vidya A Arankalle

Background

In parts of India, Chandipura Virus (CHPV) has emerged as an encephalitis causing pathogen in both epidemic and sporadic forms. This pediatric disease follows rapid course leading to 55-75% mortality. In the absence of specific treatment, effectiveness of RNA interference (RNAi) was evaluated.

Conclusions

The results highlight therapeutic potential of siRNA in treating rapid and fatal Chandipura encephalitis.

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