High-angular-sensitivity X-ray phase-contrast microtomography of soft tissue through a two-directional beam-tracking synchrotron set-up

利用双向光束跟踪同步辐射装置对软组织进行高角度灵敏度X射线相位对比显微断层扫描

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作者:Carlos Navarrete-León,P Stephen Patrick,Adam Doherty,Harry Allan,Silvia Cipiccia,Shashidhara Marathe,Kaz Wanelik,Michela Esposito,Charlotte K Hagen,Alessandro Olivo,Marco Endrizzi

Abstract

Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into an array of independent circular beamlets that are resolved by a high-resolution detector. It features isotropic spatial resolution, provides two-dimensional phase sensitivity, and enables the three-dimensional reconstructions of the refractive index decrement, δ, and the attenuation coefficient, μ. In this work, the angular sensitivity and the spatial resolution of 2DBT images in a synchrotron-based implementation is reported. In its best configuration, angular sensitivities of ∼20 nrad and spatial resolution of at least 6.25 µm in phase-contrast images were obtained. Exemplar application to the three-dimensional imaging of soft tissue samples, including a mouse liver and a decellularized porcine dermis, is also demonstrated.

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