ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway

ATF6通过调控Wnt信号通路促进结直肠癌的生长和干性

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作者:Jeffrey J Rodvold,Matthew Grimmer,Karen Ruiz,Scot A Marsters,Ioanna Oikonomidi,Eileen Tan-Aristy,Victoria C Pham,Tamal Sarkar,Jonathan M Harnoss,Whitney Shatz-Binder,Zora D Modrusan,Thomas D Wu,Jennie R Lill,Elisia Villemure,Joachim Rudolph,Felipe de Sousa E Melo,Avi Ashkenazi

Abstract

ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.

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