Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis of human NSCLC cells in mice.
High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.
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作者：Cai Ling, Hammond Nia G, Tasdogan Alpaslan, Alsamraae Massar, Yang Chendong, Cameron Robert B, Quan Peiran, Solmonson Ashley, Gu Wen, Pachnis Panayotis, Kaur Mayher, Chang Brianna K, Zhou Qin, Hensley Christopher T, Do Quyen N, Martins Nascentes Melo Luiza, Ubellacker Jessalyn M, Kaushik Akash, Clare Maia G, Alcazar Isabel N, Kurylowicz Katarzyna, Marcuccilli Joseph D, Allies Gabriele, Kutritz Andrea, Klode Joachim, Ramesh Vijayashree, Rogers Thomas J, Rao Aparna D, Crentsil Hannah E, Li Hong, Brister Fang, McDaniel Phyllis, Xu Xiaohong, Evers Bret M, Zacharias Lauren G, Sudderth Jessica, Xu Jian, Mathews Thomas P, Oliver Dwight, Minna John D, Waters John, Morrison Sean J, Kernstine Kemp H, Faubert Brandon, DeBerardinis Ralph J
| 期刊： | Cancer Discovery | 影响因子： | 33.300 |
| 时间： | 2025 | 起止号： | 2025 Apr 2; 15(4):702-716 |
| doi： | 10.1158/2159-8290.CD-23-1319 | ||
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