This study uncovered 223 recurrently mutated driver regions using the largest cohort of prostate tumors to date. It reveals associations between germline SNPs, somatic drivers, and tumor aggression, offering significant insights into how prostate tumor evolution is shaped by germline factors and the timing of somatic mutations.
The Germline and Somatic Origins of Prostate Cancer Heterogeneity.
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作者：Yamaguchi Takafumi N, Houlahan Kathleen E, Zhu Helen, Kurganovs Natalie, Livingstone Julie, Fox Natalie S, Yuan Jiapei, Sietsma Penington Jocelyn, Jung Chol-Hee, Schwarz Tommer, Jaratlerdsiri Weerachai, van Riet Job, Georgeson Peter, Mangiola Stefano, Taraszka Kodi, Lesurf Robert, Jiang Jue, Chow Ken, Heisler Lawrence E, Shiah Yu-Jia, Ramanand Susmita G, Clarkson Michael J, Nguyen Anne, Espiritu Shadrielle Melijah G, Stuchbery Ryan, Jovelin Richard, Huang Vincent, Bell Connor, O'Connor Edward, McCoy Patrick J, Lalansingh Christopher M, Cmero Marek, Salcedo Adriana, Chan Eva K F, Liu Lydia Y, Stricker Phillip D, Bhandari Vinayak, Bornman Riana M S, Sendorek Dorota H S, Lonie Andrew, Prokopec Stephenie D, Fraser Michael, Peters Justin S, Foucal Adrien, Mutambirwa Shingai B A, Mcintosh Lachlan, Orain Michèle, Wakefield Matthew, Picard Valérie, Park Daniel J, Hovington Hélène, Kerger Michael, Bergeron Alain, Sabelnykova Veronica, Seo Ji-Heui, Pomerantz Mark M, Zaitlen Noah, Waszak Sebastian M, Gusev Alexander, Lacombe Louis, Fradet Yves, Ryan Andrew, Kishan Amar U, Lolkema Martijn P, Weischenfeldt Joachim, Têtu Bernard, Costello Anthony J, Hayes Vanessa M, Hung Rayjean J, He Housheng H, McPherson John D, Pasaniuc Bogdan, van der Kwast Theodorus, Papenfuss Anthony T, Freedman Matthew L, Pope Bernard J, Bristow Robert G, Mani Ram S, Corcoran Niall M, Reimand Jüri, Hovens Christopher M, Boutros Paul C
| 期刊： | Cancer Discovery | 影响因子： | 33.300 |
| 时间： | 2025 | 起止号： | 2025 May 2; 15(5):988-1017 |
| doi： | 10.1158/2159-8290.CD-23-0882 | ||
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