Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer

CYRI-B 下调通过激活胃癌中的 Rac1-STAT3 通路促进迁移、侵袭和 EMT

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作者:Guangyao Liu, Yujian Xia, Huijin Wang, Xinghan Jin, Songyao Chen, Wei Chen, Changhua Zhang, Yulong He

Background

CYRI-B plays key roles in regulating cell motility in nontumor cells. However, the role and function of CYRI-B have rarely been studied in cancer cells, including gastric cancer. The

Conclusion

Our findings showed that CYRI-B plays an important role in the tumor microenvironment, and is associated with malignant characteristics acquired by gastric cancer. This study may provide new targets for future therapeutic interventions for tumor metastasis.

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