Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session

对多种化学物质敏感的人在受控正丁醇暴露前后的基因表达谱分析

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作者:Thomas M Dantoft, Sine Skovbjerg, Linus Andersson, Anna-Sara Claeson, Kaare Engkilde, Nina Lind, Steven Nordin, Lars I Hellgren

Conclusions

MCS participants and controls have similar gene expression levels at baseline and it was not possible to separate MCS participants from controls based on gene expression measured after the exposure.

Results

MCS participants and controls displayed similar gene expression levels both at baseline and after the exposure and the computed AUC values were likewise comparable between the 2 groups. The intragroup variation in expression levels among MCS participants was noticeably greater than the controls. Conclusions: MCS participants and controls have similar gene expression levels at baseline and it was not possible to separate MCS participants from controls based on gene expression measured after the exposure.

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