Design, synthesis and antiviral potential of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes using an efficient polymer-supported catalyst

使用高效聚合物载体催化剂设计、合成 14-芳基/杂芳基-14H-二苯并[a,j]氧杂蒽并研究其抗病毒潜力

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作者:Kalla Reddi Mohan Naidu, Balam Satheesh Krishna, Mungara Anil Kumar, Palanisamy Arulselvan, Shaik Ibrahim Khalivulla, Ola Lasekan

Abstract

Polyethyleneglycol bound sulfonic acid (PEG-OSO&sub3;H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds 3b, 3c, 3f and 3i showed highly significant anti-viral activity against tobacco mosaic virus.

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