Epigenetic and Posttranscriptional Modulation of SOS1 Can Promote Breast Cancer Metastasis through Obesity-Activated c-Met Signaling in African-American Women

SOS1 的表观遗传和转录后调节可通过肥胖激活的 c-Met 信号促进非裔美国女性乳腺癌转移

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作者:Fei Xing, Dan Zhao, Shih-Ying Wu, Abhishek Tyagi, Kerui Wu, Sambad Sharma, Yin Liu, Ravindra Deshpande, Yuezhu Wang, Jacob Cleary, Lance D Miller, Amar G Chittiboyina, Chinni Yalamanchili, Yin-Yuan Mo, Kounosuke Watabe

Significance

These findings elucidate the signaling network of SOS1-mediated metastasis in African-American patients, from the epigenetic upregulation of SOS1 to the identification of taxifolin as a potential therapeutic strategy against SOS1-driven tumor progression.

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