(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers

(R)-2-羟基戊二酸抑制 KDM5 组蛋白赖氨酸去甲基化酶，从而促进 IDH 突变癌症的转化

阅读：7

作者：Kathryn Gunn, Matti Myllykoski, John Z Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H Diplas, Michael M Levitt, Ryan Looper, John G Doench, Keith L Ligon, Harley I Kornblum, Samuel K McBrayer, Hai Yan, Cihangir Duy, Lucy A Godley, Peppi Koivunen, Julie-Aurore Losman

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2023

起止号：

2023 Jun 2;13(6):1478-1497.

doi：

10.1158/2159-8290.CD-22-0825

种属：

Mouse

方法学：

IHC

靶点：

IgG light chain

研究方向：

肿瘤

Significance

Mutant IDH is known to induce histone hypermethylation. However, it is not known if this hypermethylation is functionally significant or is a bystander effect of (R)-2HG accumulation in IDH-mutant cells. Here, we provide evidence that KDM5 inhibition by (R)-2HG contributes to mutant IDH-mediated transformation in AML and glioma. This article is highlighted in the In This Issue feature, p. 1275.

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