Data highlighting the expression of two miR-132/212 target genes-Sirt1 and Pten-after chronic stress

数据显示慢性应激后两种 miR-132/212 靶基因 Sirt1 和 Pten 的表达

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作者:Sydney Aten, Chloe E Page, Anisha Kalidindi, Kelin L Wheaton, Anzela Niraula, Jon P Godbout, Kari R Hoyt, Karl Obrietan

Abstract

The data presented here are related to our research article entitled "miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior" (Aten et al., 2018). In this article, we utilize immunofluorescent techniques to examine the protein-level expression of two microRNA-132/212 target genes, Sirt1 and Pten, in miR-132 transgenic and miR-132/212 conditional knockout (cKO) mouse lines. Additionally, using immunohistochemistry, we detail the expression profile of Sirt1 and Pten in the hippocampus and amygdala of WT mice after a 15 day chronic restraint stress paradigm.

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