TRAIL-modified, doxorubicin-embedded periodic mesoporous organosilica nanoparticles for targeted drug delivery and efficient antitumor immunotherapy

TRAIL修饰、阿霉素嵌入周期性介孔有机二氧化硅纳米粒子用于靶向药物输送和有效的抗肿瘤免疫治疗

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作者：Xinyao Feng, Fangshen Li, Liangliang Zhang, Wenmo Liu, Xupu Wang, Rui Zhu, Zhen-An Qiao, Bin Yu, Xianghui Yu
期刊：Acta Biomaterialia影响因子：9.400
时间：2022起止号：2022 Apr 15:143:392-405.
doi：10.1016/j.actbio.2022.03.001研究方向： 肿瘤

Significance

This study revealed for the first time the ability of PMOs to elevate ICD levels and activate DCs in vitro. The results explained the immunomodulatory function of PMOs and demonstrated the synergistic effects of TRAIL and DOX in triple-negative breast cancer. In addition, immunomodulatory effects of the drug delivery vectors constructed in this study were verified in vivo.

Statement of significance

This study revealed for the first time the ability of PMOs to elevate ICD levels and activate DCs in vitro. The results explained the immunomodulatory function of PMOs and demonstrated the synergistic effects of TRAIL and DOX in triple-negative breast cancer. In addition, immunomodulatory effects of the drug delivery vectors constructed in this study were verified in vivo.

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