PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms
PHGDH 表达随着阿尔茨海默病病理和症状的进展而增加
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作者:Xu Chen, Riccardo Calandrelli, John Girardini, Zhangming Yan, Zhiqun Tan, Xiangmin Xu, Annie Hiniker, Sheng Zhong
| 期刊: | Cell Metabolism | 影响因子: | 27.700 |
| 时间: | 2022 | 起止号: | 2022 May 3;34(5):651-653. |
| doi: | 10.1016/j.cmet.2022.02.008 | 研究方向: | 神经 |
| 疾病类型: | 阿尔茨海默症 | |
Abstract
Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
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