Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells

吲哚硫酸盐通过 OAT3/AhR/Stat3 通路下调近端肾小管细胞 Mas 受体的表达

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作者:Hwee-Yeong Ng, Maimaiti Yisireyili, Shinichi Saito, Chien-Te Lee, Yelixiati Adelibieke, Fuyuhiko Nishijima, Toshimitsu Niwa

Conclusion

Mas receptor expression is reduced in the kidneys of CKD rats. IS downregulates renal expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells. IS-induced downregulation of Mas receptor might be involved in upregulation of TGF-β1 in proximal tubular cells.

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