Targeting human CD27 with an agonist antibody stimulates T-cell activation and antitumor immunity
利用激动剂抗体靶向人类 CD27 可刺激 T 细胞活化和抗肿瘤免疫
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作者：Lawrence J Thomas, Li-Zhen He, Henry Marsh, Tibor Keler
| 期刊： | Oncoimmunology | 影响因子： | |
| 时间： | 2014 | 起止号： | 2014 Jan 1;3(1):e27255. |
| doi： | 10.4161/onci.27255 | 研究方向： | 免疫、肿瘤 |
| 细胞类型： | 肿瘤细胞 | |
Abstract
CD27 is an important co-stimulatory receptor of T cells that can potentially be exploited for immunotherapy. We developed a human IgG1 antibody that targets human CD27, and demonstrated its immunostimulatory and antineoplastic activity in various preclinical models. Currently, the antibody (1F5, CDX-1127) is being tested in patients affected by advanced malignancies.
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