Abstract
The Restriction Spectrum Imaging restriction score (RSIrs) has been shown to improve the accuracy for diagnosis of clinically significant prostate cancer (csPCa) compared to standard DWI. Both diffusion and T2 properties of prostate tissue contribute to the signal measured in DWI, and studies have demonstrated that each may be valuable for distinguishing csPCa from benign tissue. The purpose of this retrospective study was to (1) determine whether prostate T2 varies across RSI compartments and in the presence of csPCa, and (2) evaluate whether csPCa detection with RSIrs is improved by acquiring multiple scans at different TEs to measure compartmental T2 (cT2). Data includes two cohorts scanned for csPCa with 3T multi-b-value diffusion-weighted sequences acquired at multiple TEs. cT2 values were computed from multi-TE RSI data and compared by compartment. CsPCa detection was compared between RSIrs and a logistic regression model (LRM) to predict the probability of csPCa using cT2 in combination with RSI measurements. Two-sample t-tests (α = 0.05) and the area under the receiver operating characteristic curve (AUC) were used for the statistical analyses. In both cohorts, T2 was different (p < 0.05) across the four RSI compartments (C1, C2, C3, C4). Voxel-level, cohort 1: T2 was different in csPCa for C1, C2, C3 (p < 0.001). Patient-level, cohort 1: T2 was different in csPCa patients in C3 (p = 0.02); cohort 2: T2 differed in csPCa patients in C1 (p = 0.01), C3 (p = 0.01) and C4 (p < 0.01). Voxel-level csPCa detection: cT2 did not improve discrimination over RSIrs alone (p = 0.9). Patient-level: RSIrs and the LRM performed better than diffusion alone (p < 0.001), but the difference in AUCs between RSIrs and the LRM was not significantly different (p = 0.54). In conclusion, significant differences in cT2 were observed between normal and cancerous prostatic tissue. With our data, however, consideration of cT2 in addition to diffusion did not significantly improve cancer detection performance.