The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers

白血病对短串联重复序列 (STR) 标记检测的影响

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作者:Sara F Alharbi, Asim Alamri, Ahmed Elshehawi

Conclusion

Our results demonstrate that STR markers could become useful in genetic studies of leukemia cases.

Methods

DNA was isolated from 30 participants (15 with chronic myeloid leukemia( CML) and 15 healthy controls) and used to amplify STR markers using specific primers.

Results

We found that the blood of those with leukemia had more 9.3 and 9 alleles at the tyrosine hydroxylase 1 (TH01) marker than the blood of the healthy control samples. The results of this study will help researchers understand leukemia's effect on the detection and stability of STR markers in leukemic patients compared to healthy individuals.

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