Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

KEAP1/NRF2 和 TP53 突变在肺鳞状细胞癌发展和放射抗性中的作用

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作者：Youngtae Jeong, Ngoc T Hoang, Alexander Lovejoy, Henning Stehr, Aaron M Newman, Andrew J Gentles, William Kong, Diana Truong, Shanique Martin, Aadel Chaudhuri, Diane Heiser, Li Zhou, Carmen Say, Justin N Carter, Susan M Hiniker, Billy W Loo Jr, Robert B West, Philip Beachy, Ash A Alizadeh, Maximilia

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2017

起止号：

2017 Jan;7(1):86-101.

doi：

10.1158/2159-8290.CD-16-0127

研究方向：

免疫、细胞生物学

疾病类型：

肺癌

细胞类型：

肿瘤细胞

Significance

We developed an LSCC mouse model involving Trp53 and Keap1, which are frequently mutated in human LSCCs. In this model, ABSCs are the cell of origin of these tumors. KEAP1/NRF2 mutations increase radioresistance and predict local tumor recurrence in radiotherapy patients. Our findings are of potential clinical relevance and could lead to personalized treatment strategies for tumors with KEAP1/NRF2 mutations. Cancer Discov; 7(1); 86-101. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 1.

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