Abstract
Cellulose-based advanced materials, such as cellulose nanocrystals (CNC), have high potential application for drug delivery system. In this study, the CNC were produced from bamboo shoots using acid hydrolysis process. The delignification of bamboo shoots was conducted using alkali and hydrogen peroxide pretreatment processes. The operating condition of the production of CNC from bamboo shoots was optimized using Response Surface Methodology (RSM) based on the yield and crystals recovery as the responses. The optimum CNC yield of 50.67 ± 0.74% with a crystals recovery of 77.99 ± 1.14% was obtained at the sulfuric acid concentration of 54.73 wt% and a temperature of 39 °C from the optimization based on the yield. This optimization has been validated to confirm the accuracy.